DAMASCUS/GAZA - An Israeli drone attack targeted and destroyed a weapons depot in the coastal Syrian city of Jableh before daybreak Thursday, the Syrian Observatory for Human Rights reported.

The war monitor also reported that two Lebanese nationals, including Hassan Jafar Qasir, the son-in-law of late Hezbollah leader, Sayyed Hassan Nasrallah, were killed in an Israeli airstrike on a residence in the Mazzeh Western Villas neighborhood of Damascus on Wednesday.

The attack in Jableh, which was carried out via drones and warplane missiles, leveled the depot and caused massive explosions heard from long distances, said the UK-based monitor.

It added that the Syrian air defenses and Russian forces responded to the attack within 40 to 50 minutes. The depot is situated near the Hmeimim Air Base, the largest Russian air base in Syria, located in the northwestern province of Latakia.

No immediate reports of casualties have been reported.

While there is no official confirmation, the pro-government Sham FM radio said the sounds heard in the skies over Jableh were the air defenses intercepting targets off the coast.

It added that firefighting teams headed to a site in the vicinity of Jableh after columns of fire were seen rising from it, but no information was provided about its nature.

This latest attack follows a series of Israeli airstrikes in Syria this week.

In Damascus, an Israeli strike earlier hit the first floor of a three-story building frequented by Hezbollah and Iranian Revolutionary Guard Corps leaders, killing three people, including two non-Syrians, and injuring at least four others whose identities remain unknown.

The attack follows a previous Israeli strike on the neighborhood in January, which killed 13 people, including five Iranians.

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The Syrian Defense Ministry said three civilians were killed and three others injured in the strike. The ministry said the attack was launched from the Israeli-occupied Golan Heights.

Israel killed Nasrallah in a powerful airstrike in the Lebanese capital Beirut on Sept 27.

On Tuesday morning, Israel targeted a site approximately 500 meters from Wednesday's strike, killing three people, including a journalist, and injuring nine others.

In Gaza, three Palestinians were killed and 15 others injured in an Israeli airstrike in the central part of the enclave, said Palestinian sources on Wednesday.

The Civil Defense in Gaza said in a press statement that its team recovered the bodies and injuries from the Nuseirat Elementary School housing displaced persons in the Nuseirat camp in central Gaza.

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Local eyewitnesses told Xinhua that an Israeli warplane bombed the Nuseirat Elementary School with at least one missile, causing heavy damage to the infrastructure.

Israeli army spokesperson Avichay Adraee said in a press statement that with intelligence guidance, the Israeli air force carried out a strike on "terrorists who were operating in a command and control complex in an area previously used as the Nuseirat Girls School in central Gaza".

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The statement added that the command and control complex was used by Hamas members "to plan and carry out terrorist operations against IDF forces and the State of Israel".

Israel launched a large-scale offensive against Hamas in Gaza to retaliate against a Hamas rampage through the southern Israeli border on Oct 7, 2023, during which 1,200 people were killed and about 250 others taken hostage.

The Palestinian death toll from ongoing Israeli attacks in the strip has risen to 41,689, the Gaza-based health authorities said in a statement on Wednesday.