TOKYO - Wall Street futures sank and the safe-haven yen and Swiss franc strengthened on Monday.
US S&P 500 stock futures pointed 0.5 percent lower and Nasdaq futures sagged 0.6 percent as of 0609 GMT.
Japan's Nikkei was 0.4 percent higher after flipping between small gains and losses. The yen strengthened some 0.6 percent to 147.245 per dollar, while the franc rose 0.4 percent to 0.8773 per dollar.
European markets offered a bright spot though, with pan-European STOXX 50 futures pointing up 0.55 percent.
Elsewhere, US President Donald Trump in a Fox News interview on Sunday declined to predict whether his tariffs on Canada and Mexico would result in a US recession.
A run of soft US economic data continued on Friday after monthly figures showed the labor market created fewer jobs than expected in February, in the first payrolls report capturing Trump's policies.
"I think it's Trump's cavalier approach to economic policy that's rattling sentiment," said Kyle Rodda, senior financial markets analyst at Capital.com.
"Unlike during his first administration, where signs of an economic slowdown or market correction would see a pivot on policy, he is genuinely focused on significant, structural change to the economy - even if it comes at the expense of short-term growth."
US Treasury yields slid, with the 10-year yield dropping as much as 6 basis points (bps) to 4.257 percent and the two-year yield dipping 4.5 bps to 3.956 percent.
The US dollar index, which measures the currency against six major peers, added 0.1 percent to 103.82, reversing earlier small losses.
The euro gained 0.3 percent to $1.0866 and sterling rose 0.2 percent to $1.2946.
In his latest warning to Canada, Trump said on Friday that reciprocal tariffs on dairy and lumber could be imminent.
"For those struggling to keep up, that means that Canadian tariffs were imposed on Tuesday, tweaked on Wednesday, delayed on Thursday, then expanded again on Friday," said Michael Brown, senior research strategist at Pepperstone.
"In that sort of an environment, it is frankly impossible for any market participant to price risk."
Brent was down 0.4 percent at $70.11 a barrel on Monday and US West Texas Intermediate crude down by a similar margin to $66.76 a barrel.
Gold, another traditional haven asset, added 0.15 percent to $2,915 an ounce.
Cryptocurrency bitcoin lost as much as 7.2 percent from Friday to reach the lowest this month at $80,085.42.
Optimism about looser regulation and the creation of a cryptocurrency reserve under Trump lifted the token to an all-time high of $109,071.86 in January, but it has struggled since.
The long-awaited executive order on creating the reserve came on Friday, but disappointed many investors by saying there would be no additional buying of bitcoin.